WebShumiya cataract rat (SCR) is a hereditary cataractous rat strain that develops cataract at approximate 11 weeks of age . Lss gene is mutated in SCR and is the major gene for cataract onset [ 19 ]. In humans, two distinct homozygous LSS missense mutations (W581R and G588S) happen in two families with extensive congenital cataracts, which impairs key … WebThe role of proteolytic enzymes in Shumiya cataract rats in alterations to lens proteins during cataract formation was studied immunohistochemically using antibodies against …
Seigo Shumiya
WebPurpose: To conduct a long-term observation study of SCR rats that had developed a mature cataract at 11 weeks of age at 3-month intervals until the rats were 12 months old. Methods: Lenses of 15 rats were examined with both light and electron microscopes.. Results: At 12 weeks, opacity was observed in the perinuclear zone and the cortical intermediate layer. WebWe demonstrate a delaying effect of deep-sea drinking water (DDW) containing enhanced magnesium ion (Mg 2 +) and calcium ion (Ca 2 +) concentrations on cataract … five nights at freddy\u0027s pirate cove
The Intravitreal Injection of Lanosterol ... - Semantic Scholar
WebThe Shumiya cataract rat (SCR) and normal control rat strains of NC1 and NC2 were established. Mean cataract appearance in adult SCR rats was 66.7%, and embryo death … WebOct 25, 2024 · By positional cloning and genotyping in Shumiya cataract rats, Mori et al. (2006) identified hypomorphic mutations in the Lss gene and the Fdft1 gene, as well as a null mutation in Lss.Cataract onset was associated with the specific combination of Lss and Fdft1 mutant alleles that decreased cholesterol levels in cataractous lenses to about 57% … WebAug 4, 2024 · Six-week-old Shumiya cataract rats were used to perform experiments. The right eye of each rat was injected with TAT-HA-Prdx6 WT-NPs or TAT-HA-Prdx6 K122/142R-NPs, whereas the left eyes were administered with TAT-HA-Prdx6 Inactive-mutant-NPs. The subconjuctival injection was made using micro-syringes fitted with 30-gauge needles. five nights at freddy\u0027s piper rubio